A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases

We present a rapid and powerful inference procedure for identifying loci associated with rare hereditary disorders using Bayesian model comparison. Under a baseline model, disease risk is fixed across all individuals in a study. Under an association model, disease risk depends on a latent bipartitio...

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Detalles Bibliográficos
Autores principales: Greene, Daniel, Richardson, Sylvia, Turro, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501869/
https://www.ncbi.nlm.nih.gov/pubmed/28669401
http://dx.doi.org/10.1016/j.ajhg.2017.05.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501869/
https://www.ncbi.nlm.nih.gov/pubmed/28669401
http://dx.doi.org/10.1016/j.ajhg.2017.05.015

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