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Regulation of early growth response 2 expression by secreted frizzled related protein 1

BACKGROUND: Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers, including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation. Additionally, loss of SFRP1 enhances TGF-β signaling and the downstream MAPK pathway. TGF-β has...

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Detalles Bibliográficos
Autores principales: Gregory, Kelly J., Morin, Stephanie M., Schneider, Sallie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501954/
https://www.ncbi.nlm.nih.gov/pubmed/28687085
http://dx.doi.org/10.1186/s12885-017-3426-y