Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms

Despite extensive effort, there has been limited progress in the development of direct RAS inhibitors. Targeting isoprenylcysteine carboxylmethyltransferase (ICMT), a unique enzyme of RAS post-translational modification, represents a promising strategy to inhibit RAS function. However, there lacks d...

Descripción completa

Detalles Bibliográficos
Autores principales: Lau, H Y, Tang, J, Casey, P J, Wang, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502315/
https://www.ncbi.nlm.nih.gov/pubmed/28192404
http://dx.doi.org/10.1038/onc.2016.508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502315/
https://www.ncbi.nlm.nih.gov/pubmed/28192404
http://dx.doi.org/10.1038/onc.2016.508

Ejemplares similares