Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

The treatment of chronic mucocutaneous ulceration is challenging, and only some patients respond selectively to inhibitors of tumor necrosis factor-α (TNF). TNF activates opposing pathways leading to caspase-8–mediated apoptosis as well as nuclear factor κB (NF-κB)–dependent cell survival. We invest...

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Detalles Bibliográficos
Autores principales: Badran, Yousef R., Dedeoglu, Fatma, Leyva Castillo, Juan Manuel, Bainter, Wayne, Ohsumi, Toshiro K., Bousvaros, Athos, Goldsmith, Jeffrey D., Geha, Raif S., Chou, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502421/
https://www.ncbi.nlm.nih.gov/pubmed/28600438
http://dx.doi.org/10.1084/jem.20160724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502421/
https://www.ncbi.nlm.nih.gov/pubmed/28600438
http://dx.doi.org/10.1084/jem.20160724

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