TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid–containing immune complexes (IC) drive inflammation. The role of Toll-like receptor (TLR) signaling in processing of SL...

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Detalles Bibliográficos
Autores principales: Lood, Christian, Arve, Sabine, Ledbetter, Jeffrey, Elkon, Keith B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502427/
https://www.ncbi.nlm.nih.gov/pubmed/28606989
http://dx.doi.org/10.1084/jem.20161512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502427/
https://www.ncbi.nlm.nih.gov/pubmed/28606989
http://dx.doi.org/10.1084/jem.20161512

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