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TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA
Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid–containing immune complexes (IC) drive inflammation. The role of Toll-like receptor (TLR) signaling in processing of SL...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502427/ https://www.ncbi.nlm.nih.gov/pubmed/28606989 http://dx.doi.org/10.1084/jem.20161512 |