Single-molecule analysis of ligand efficacy in β(2)AR-G protein activation

G protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signaling responses remain poorly understood. In Class A GPCRs, receptor activation and G protein coupling entail outw...

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Detalles Bibliográficos
Autores principales: Gregorio, G. Glenn, Masureel, Matthieu, Hilger, Daniel, Terry, Daniel S., Juette, Manuel, Zhao, Hong, Zhou, Zhou, Perez-Aguilar, Jose Manuel, Hauge, Maria, Mathiasen, Signe, Javitch, Jonathan A., Weinstein, Harel, Kobilka, Brian K., Blanchard, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502743/
https://www.ncbi.nlm.nih.gov/pubmed/28607487
http://dx.doi.org/10.1038/nature22354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502743/
https://www.ncbi.nlm.nih.gov/pubmed/28607487
http://dx.doi.org/10.1038/nature22354

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