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Single-molecule analysis of ligand efficacy in β(2)AR-G protein activation

G protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signaling responses remain poorly understood. In Class A GPCRs, receptor activation and G protein coupling entail outw...

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Detalles Bibliográficos
Autores principales:	Gregorio, G. Glenn, Masureel, Matthieu, Hilger, Daniel, Terry, Daniel S., Juette, Manuel, Zhao, Hong, Zhou, Zhou, Perez-Aguilar, Jose Manuel, Hauge, Maria, Mathiasen, Signe, Javitch, Jonathan A., Weinstein, Harel, Kobilka, Brian K., Blanchard, Scott C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502743/ https://www.ncbi.nlm.nih.gov/pubmed/28607487 http://dx.doi.org/10.1038/nature22354

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