Enhanced immunization via dissolving microneedle array-based delivery system incorporating subunit vaccine and saponin adjuvant

PURPOSE: To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS: OVA-...

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Detalles Bibliográficos
Autores principales: Zhao, Ji-Hui, Zhang, Qi-Bo, Liu, Bao, Piao, Xiang-Hua, Yan, Yu-Lu, Hu, Xiao-Ge, Zhou, Kuan, Zhang, Yong-Tai, Feng, Nian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503490/
https://www.ncbi.nlm.nih.gov/pubmed/28740383
http://dx.doi.org/10.2147/IJN.S132456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503490/
https://www.ncbi.nlm.nih.gov/pubmed/28740383
http://dx.doi.org/10.2147/IJN.S132456

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