Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7

HnRNP A1 regulates many alternative splicing events by the recognition of splicing silencer elements. Here, we provide the solution structures of its two RNA recognition motifs (RRMs) in complex with short RNA. In addition, we show by NMR that both RRMs of hnRNP A1 can bind simultaneously to a singl...

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Detalles Bibliográficos
Autores principales: Beusch, Irene, Barraud, Pierre, Moursy, Ahmed, Cléry, Antoine, Allain, Frédéric Hai-Trieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503513/
https://www.ncbi.nlm.nih.gov/pubmed/28650318
http://dx.doi.org/10.7554/eLife.25736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503513/
https://www.ncbi.nlm.nih.gov/pubmed/28650318
http://dx.doi.org/10.7554/eLife.25736

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