Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R

Tuberous sclerosis complex (TSC) is a multisystem disease associated with hyperactive mTORC1. The impact of TSC1/2 deficiency on lysosome-mediated processes is not fully understood. We report here that inhibition of lysosomal function using chloroquine (CQ) upregulates cholesterol homeostasis genes...

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Detalles Bibliográficos
Autores principales: Filippakis, Harilaos, Alesi, Nicola, Ogorek, Barbara, Nijmeh, Julie, Khabibullin, Damir, Gutierrez, Catherine, Valvezan, Alexander J., Cunningham, James, Priolo, Carmen, Henske, Elizabeth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503518/
https://www.ncbi.nlm.nih.gov/pubmed/28498820
http://dx.doi.org/10.18632/oncotarget.17485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503518/
https://www.ncbi.nlm.nih.gov/pubmed/28498820
http://dx.doi.org/10.18632/oncotarget.17485

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