Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

The role of paracrine Hepatocyte Growth Factor (HGF) in the resistance to angiogenesis inhibitors (AIs) is hidden in xenograft models because mouse HGF fails to fully activate human MET. To uncover it, we compared the efficacy of AIs in wild-type and human HGF knock-in SCID mice bearing orthotopic h...

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Detalles Bibliográficos
Autores principales: Mira, Alessia, Morello, Virginia, Céspedes, Maria Virtudes, Perera, Timothy, Comoglio, Paolo M., Mangues, Ramon, Michieli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Autophagy and Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503526/
https://www.ncbi.nlm.nih.gov/pubmed/28445144
http://dx.doi.org/10.18632/oncotarget.16942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503526/
https://www.ncbi.nlm.nih.gov/pubmed/28445144
http://dx.doi.org/10.18632/oncotarget.16942

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