Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene

In gene therapy, effective and selective suicide gene expression is crucial. We exploited the endogenous Long INterspersed Element-1 (L1) machinery often reactivated in human cancers to integrate the Herpes Simplex Virus Thymidine Kinase (HSV-TK) suicide gene selectively into the genome of cancer ce...

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Detalles Bibliográficos
Autores principales: Chendeb, Mariam, Schneider, Robert, Davidson, Irwin, Fadloun, Anas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503529/
https://www.ncbi.nlm.nih.gov/pubmed/28415677
http://dx.doi.org/10.18632/oncotarget.16013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503529/
https://www.ncbi.nlm.nih.gov/pubmed/28415677
http://dx.doi.org/10.18632/oncotarget.16013

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