Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells

Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability to export cargos. Pre...

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Detalles Bibliográficos
Autores principales: Burke, Russell T., Marcus, Joshua M., Orth, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503625/
https://www.ncbi.nlm.nih.gov/pubmed/28467801
http://dx.doi.org/10.18632/oncotarget.17063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503625/
https://www.ncbi.nlm.nih.gov/pubmed/28467801
http://dx.doi.org/10.18632/oncotarget.17063

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