Cargando…
Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells
Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability to export cargos. Pre...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503625/ https://www.ncbi.nlm.nih.gov/pubmed/28467801 http://dx.doi.org/10.18632/oncotarget.17063 |