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Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis
Map3k8 has been proposed as a useful target for the treatment of inflammatory diseases. We show here that during lipopolysaccharide-induced emergency granulopoiesis, Map3k8 deficiency strongly impairs the increase in circulating mature (Ly6G(high)CD11b(+)) and immature (Ly6G(low)CD11b(+)) neutrophil...
Autores principales: | Sánchez, Ángela, Relaño, Carlos, Carrasco, Araceli, Contreras-Jurado, Constanza, Martín-Duce, Antonio, Aranda, Ana, Alemany, Susana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503936/ https://www.ncbi.nlm.nih.gov/pubmed/28694430 http://dx.doi.org/10.1038/s41598-017-04538-3 |
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