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Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions. However, the delineation of pathological and physiological roles of C3 has been hampe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503937/ https://www.ncbi.nlm.nih.gov/pubmed/28694465 http://dx.doi.org/10.1038/s41598-017-05400-2 |