Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state and bound to the αβ-tubulin heterodimer, a com...

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Detalles Bibliográficos
Autores principales: Wang, Weiyi, Cantos-Fernandes, Soraya, Lv, Yuncong, Kuerban, Hureshitanmu, Ahmad, Shoeb, Wang, Chunguang, Gigant, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503940/
https://www.ncbi.nlm.nih.gov/pubmed/28694425
http://dx.doi.org/10.1038/s41467-017-00091-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503940/
https://www.ncbi.nlm.nih.gov/pubmed/28694425
http://dx.doi.org/10.1038/s41467-017-00091-9

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