Analysis of positive and negative allosteric modulation in metabotropic glutamate receptors 4 and 5 with a dual ligand

As class C GPCRs and regulators of synaptic activity, human metabotropic glutamate receptors (mGluRs) 4 and 5 are prime targets for allosteric modulation, with mGlu5 inhibition or mGlu4 stimulation potentially treating conditions like chronic pain and Parkinson’s disease. As an allosteric modulator...

Descripción completa

Detalles Bibliográficos
Autores principales: Dalton, James A. R., Pin, Jean-Philippe, Giraldo, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504000/
https://www.ncbi.nlm.nih.gov/pubmed/28694498
http://dx.doi.org/10.1038/s41598-017-05095-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504000/
https://www.ncbi.nlm.nih.gov/pubmed/28694498
http://dx.doi.org/10.1038/s41598-017-05095-5

Ejemplares similares