Cargando…

Presence of diabetes autoantigens in extracellular vesicles derived from human islets

Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the mechanisms by which autoreactive responses are generated in susceptible individuals are not well understood. Extracellular vesicles (EV) are produced by mammalian cells under normal and stressed physiological states. They...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hasilo, Craig P., Negi, Sarita, Allaeys, Isabelle, Cloutier, Nathalie, Rutman, Alissa K., Gasparrini, Marco, Bonneil, Éric, Thibault, Pierre, Boilard, Éric, Paraskevas, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504025/ https://www.ncbi.nlm.nih.gov/pubmed/28694505 http://dx.doi.org/10.1038/s41598-017-04977-y

Ejemplares similares

Extracellular Vesicles From Kidney Allografts Express miR-218-5p and Alter Th17/Treg Ratios
por: Rutman, Alissa K., et al.
Publicado: (2022)

Analysis of Beta-Cell Gene Expression Reveals Inflammatory Signaling and Evidence of Dedifferentiation following Human Islet Isolation and Culture
por: Negi, Sarita, et al.
Publicado: (2012)

Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses
por: Marcoux, Geneviève, et al.
Publicado: (2016)

Platelet-derived microparticles serve as an important source of autoantigens and discriminate between levels of disease activity in systemic lupus erythematosus
por: Boilard, Eric, et al.
Publicado: (2014)

Essentials of extracellular vesicles: posters on basic and clinical aspects of extracellular vesicles
por: Nieuwland, Rienk, et al.
Publicado: (2018)

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes
por: Cloutier, Nathalie, et al.
Publicado: (2013)

SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB
por: Lacasse, Émile, et al.
Publicado: (2023)

Extracellular vesicles are present in mouse lymph and their level differs in atherosclerosis
por: Milasan, Andreea, et al.
Publicado: (2016)

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age
por: Grenier‐Pleau, Isabelle, et al.
Publicado: (2020)

An in vitro Perfused Macroencapsulation Device to Study Hemocompatibility and Survival of Islet-Like Cell Clusters
por: Fernandez, Stephanie A., et al.
Publicado: (2021)

Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts
por: Dieudé, Mélanie, et al.
Publicado: (2019)

A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow’s milk
por: Benmoussa, Abderrahim, et al.
Publicado: (2017)

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
por: Tian, Jide, et al.
Publicado: (1997)

Local Autoantigen Expression as Essential Gatekeeper of Memory T-Cell Recruitment to Islet Grafts in Diabetic Hosts
por: Alkemade, Gonnie M., et al.
Publicado: (2013)

CD8(+) T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage
por: Fuchs, Yannick F., et al.
Publicado: (2017)

Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis
por: Laroche, Audree, et al.
Publicado: (2022)

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs
por: Hardy, Marie-Pierre, et al.
Publicado: (2019)

Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes
por: Wei, Junlun, et al.
Publicado: (2023)

Immunogenicity of autoantigens
por: Backes, Christina, et al.
Publicado: (2011)

Red blood cell-derived phosphatidylserine positive extracellular vesicles are associated with past thrombotic events in patients with systemic erythematous lupus
por: Hasse, Stephan, et al.
Publicado: (2022)

The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512
por: Mziaut, Hassan, et al.
Publicado: (2016)

Directed migration: Cells navigate by extracellular vesicles
por: Sung, Bong Hwan, et al.
Publicado: (2018)

Purification Methods and the Presence of RNA in Virus Particles and Extracellular Vesicles
por: Zhou, Yijun, et al.
Publicado: (2020)

RNA helicase DDX3X modulates herpes simplex virus 1 nuclear egress
por: Khadivjam, Bita, et al.
Publicado: (2023)

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
por: Beillevaire, Déborah, et al.
Publicado: (2022)

Neutrophil Extracellular DNA Traps Induce Autoantigen Production by Airway Epithelial Cells
por: Choi, Youngwoo, et al.
Publicado: (2017)

Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens
por: Qiu, Connie C., et al.
Publicado: (2019)

THE ANTIGENS AND AUTOANTIGENS OF THE SEMINAL VESICLE : I. IMMUNOCHEMICAL STUDIES ON GUINEA PIG VESICULAR FLUID
por: Orsini, Frank, et al.
Publicado: (1971)

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice
por: Dubuc, Isabelle, et al.
Publicado: (2022)

Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA
por: Becker, Yann, et al.
Publicado: (2019)

Thermoneutrality and severe malaria: investigating the effect of warmer environmental temperatures on the inflammatory response and disease progression
por: Vialard, Fiorella, et al.
Publicado: (2023)

Investigation of the Presence of DNA in Human Blood Plasma Small Extracellular Vesicles
por: Lichá, Kristína, et al.
Publicado: (2023)

Extracellular Vesicles—Connecting Kingdoms
por: Woith, Eric, et al.
Publicado: (2019)

Engineering Vascularized Islet Macroencapsulation Devices: An in vitro Platform to Study Oxygen Transport in Perfused Immobilized Pancreatic Beta Cell Cultures
por: S. A., Fernandez, et al.
Publicado: (2022)

Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells
por: Puhm, Florian, et al.
Publicado: (2022)

Identification of T-cell specific autoantigens
por: Hamann, D, et al.
Publicado: (2002)

Death, autoantigen modifications, and tolerance
por: Utz,, Paul J, et al.
Publicado: (2000)

Interferon and autoantigens: intersection in autoimmunity
por: Antiochos, Brendan, et al.
Publicado: (2023)

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations
por: Becker, Yann, et al.
Publicado: (2019)

Identification of a New Autoantigen in Type 1 Diabetes♦: Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_j8cu44ahd2q7hsn0dfo2n5cpnu