Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease

Lon, also known as Protease La, is one of the simplest ATP-dependent proteases. It is a homooligomeric enzyme comprised of an ATPase domain and a proteolytic domain in each enzyme subunit. Despite sharing about 40% sequence identity, human and Escherichia coli Lon proteases utilize a highly conserve...

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Detalles Bibliográficos
Autores principales: Fishovitz, Jennifer, Sha, Zhou, Chilakala, Sujatha, Cheng, Iteen, Xu, Yan, Lee, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504276/
https://www.ncbi.nlm.nih.gov/pubmed/28744459
http://dx.doi.org/10.3389/fmolb.2017.00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504276/
https://www.ncbi.nlm.nih.gov/pubmed/28744459
http://dx.doi.org/10.3389/fmolb.2017.00047

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