Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures

BACKGROUND: Industrial processes for recombinant protein production challenge production hosts, such as the yeast Pichia pastoris, on multiple levels. During a common P. pastoris fed-batch process, cells experience strong adaptations to different metabolic states or suffer from environmental stresse...

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Detalles Bibliográficos
Autores principales: Burgard, Jonas, Valli, Minoska, Graf, Alexandra B., Gasser, Brigitte, Mattanovich, Diethard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504661/
https://www.ncbi.nlm.nih.gov/pubmed/28693509
http://dx.doi.org/10.1186/s12934-017-0730-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504661/
https://www.ncbi.nlm.nih.gov/pubmed/28693509
http://dx.doi.org/10.1186/s12934-017-0730-9

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