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Biomarkers allow detection of nutrient limitations and respective supplementation for elimination in Pichia pastoris fed-batch cultures

BACKGROUND: Industrial processes for recombinant protein production challenge production hosts, such as the yeast Pichia pastoris, on multiple levels. During a common P. pastoris fed-batch process, cells experience strong adaptations to different metabolic states or suffer from environmental stresse...

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Detalles Bibliográficos
Autores principales:	Burgard, Jonas, Valli, Minoska, Graf, Alexandra B., Gasser, Brigitte, Mattanovich, Diethard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504661/ https://www.ncbi.nlm.nih.gov/pubmed/28693509 http://dx.doi.org/10.1186/s12934-017-0730-9

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