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The attenuation of renal fibrosis by histone deacetylase inhibitors is associated with the plasticity of FOXP3(+)IL-17(+) T cells

BACKGROUND: The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4(+) forkhead box P3 (FOXP3)(+) T regulatory (Treg) cells may be converted to inflammation-associated T helper 17 cells (Th17) with tissue f...

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Detalles Bibliográficos
Autores principales: Wu, Wen-Pyng, Tsai, Yi-Giien, Lin, Tze-Yi, Wu, Ming-Ju, Lin, Ching-Yuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504832/
https://www.ncbi.nlm.nih.gov/pubmed/28693431
http://dx.doi.org/10.1186/s12882-017-0630-6