Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL

Human tumor necrosis factor-related apoptosis-inducing ligand (hTRAIL) has exhibited superior in vitro cytotoxicity in a variety of tumor cells. However, hTRAIL showed a disappointing anticancer effect in clinical trials, although hTRAIL-based regimens were well tolerated. One important reason might...

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Detalles Bibliográficos
Autores principales: Tao, Ze, Yang, Hao, Shi, Qiuxiao, Fan, Qing, Wan, Lin, Lu, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505058/
https://www.ncbi.nlm.nih.gov/pubmed/28740549
http://dx.doi.org/10.7150/thno.19091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505058/
https://www.ncbi.nlm.nih.gov/pubmed/28740549
http://dx.doi.org/10.7150/thno.19091

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