A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

BACKGROUND: Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of Parkinson’s disease. However, the function and molecular pathways regulated by LRRK2 are largely unknown. It has been shown that LR...

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Detalles Bibliográficos
Autores principales: Salašová, Alena, Yokota, Chika, Potěšil, David, Zdráhal, Zbyněk, Bryja, Vítězslav, Arenas, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505151/
https://www.ncbi.nlm.nih.gov/pubmed/28697798
http://dx.doi.org/10.1186/s13024-017-0193-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505151/
https://www.ncbi.nlm.nih.gov/pubmed/28697798
http://dx.doi.org/10.1186/s13024-017-0193-9

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