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Deletion of RhoA in Progesterone Receptor–Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice

Ras homolog gene family, member A (RhoA) is widely expressed throughout the female reproductive system. To assess its role in progesterone receptor-expressing cells, we generated RhoA conditional knockout mice RhoA(d/d) (RhoA(f/f)-Pgr-Cre(+/−)). RhoA(d/d) female mice had comparable mating activity,...

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Detalles Bibliográficos
Autores principales: El Zowalaty, Ahmed E., Li, Rong, Zheng, Yi, Lydon, John P., DeMayo, Francesco J., Ye, Xiaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505209/
https://www.ncbi.nlm.nih.gov/pubmed/28498971
http://dx.doi.org/10.1210/en.2016-1796