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H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos

Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient, and the development of the resultant embryos is frequently compromised, in part due to the inappropriate expression of genes previously activ...

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Detalles Bibliográficos
Autores principales: Hörmanseder, Eva, Simeone, Angela, Allen, George E., Bradshaw, Charles R., Figlmüller, Magdalena, Gurdon, John, Jullien, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505866/
https://www.ncbi.nlm.nih.gov/pubmed/28366589
http://dx.doi.org/10.1016/j.stem.2017.03.003