A novel STK1-targeted small-molecule as an “antibiotic resistance breaker” against multidrug-resistant Staphylococcus aureus

Ser/Thr protein kinase (STK1) plays a critical role in cell wall biosynthesis of and drug resistance in methicillin-resistant Staphylococcus aureus (MRSA). MRSA strains lacking STK1 become susceptible to failing cephalosporins, such as Ceftriaxone and Cefotaxime. STK1, despite being nonessential pro...

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Detalles Bibliográficos
Autores principales: Kant, Sashi, Asthana, Shailendra, Missiakas, Dominique, Pancholi, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505960/
https://www.ncbi.nlm.nih.gov/pubmed/28698584
http://dx.doi.org/10.1038/s41598-017-05314-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505960/
https://www.ncbi.nlm.nih.gov/pubmed/28698584
http://dx.doi.org/10.1038/s41598-017-05314-z

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