Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Our research introduces the natural flavonoid naringenin as a novel inhibitor of an emerging class of intracellular channels, Two-Pore Channel 2 (TPC2), as shown by electrophysiological evidence in a heterologous system, i.e. Arabidopsis vacuoles lacking endogenous TPCs. In view of the control exert...

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Detalles Bibliográficos
Autores principales: Pafumi, Irene, Festa, Margherita, Papacci, Francesca, Lagostena, Laura, Giunta, Cristina, Gutla, Vijay, Cornara, Laura, Favia, Annarita, Palombi, Fioretta, Gambale, Franco, Filippini, Antonio, Carpaneto, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505983/
https://www.ncbi.nlm.nih.gov/pubmed/28698624
http://dx.doi.org/10.1038/s41598-017-04974-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505983/
https://www.ncbi.nlm.nih.gov/pubmed/28698624
http://dx.doi.org/10.1038/s41598-017-04974-1

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