Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its r...

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Detalles Bibliográficos
Autores principales: Lawrence, K. M., Jones, R. C., Jackson, T. R., Baylie, R. L., Abbott, B., Bruhn-Olszewska, B., Board, T. N., Locke, I. C., Richardson, S. M., Townsend, P. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505992/
https://www.ncbi.nlm.nih.gov/pubmed/28698554
http://dx.doi.org/10.1038/s41598-017-04367-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505992/
https://www.ncbi.nlm.nih.gov/pubmed/28698554
http://dx.doi.org/10.1038/s41598-017-04367-4

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