The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calciu...

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Detalles Bibliográficos
Autores principales: Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506014/
https://www.ncbi.nlm.nih.gov/pubmed/28698627
http://dx.doi.org/10.1038/s41598-017-05052-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506014/
https://www.ncbi.nlm.nih.gov/pubmed/28698627
http://dx.doi.org/10.1038/s41598-017-05052-2

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