Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane

Within macrophages and amoeba, the Legionella-containing vacuole (LCV) membrane is derived from the ER. The bona fide F-box AnkB effector protein of L. pneumophila strain AA100/130b is anchored to the cytosolic side of the LCV membrane through host-mediated farnesylation of its C-terminal eukaryotic...

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Detalles Bibliográficos
Autores principales: Perpich, John D., Kalia, Awdhesh, Price, Christopher T. D., Jones, Snake C., Wong, Kathy, Gehring, Kalle, Kwaik, Yousef Abu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506055/
https://www.ncbi.nlm.nih.gov/pubmed/28698607
http://dx.doi.org/10.1038/s41598-017-05211-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506055/
https://www.ncbi.nlm.nih.gov/pubmed/28698607
http://dx.doi.org/10.1038/s41598-017-05211-5

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