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Divergent evolution of Di-lysine ER retention vs. farnesylation motif-mediated anchoring of the AnkB virulence effector to the Legionella-containing vacuolar membrane

Within macrophages and amoeba, the Legionella-containing vacuole (LCV) membrane is derived from the ER. The bona fide F-box AnkB effector protein of L. pneumophila strain AA100/130b is anchored to the cytosolic side of the LCV membrane through host-mediated farnesylation of its C-terminal eukaryotic...

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Detalles Bibliográficos
Autores principales:	Perpich, John D., Kalia, Awdhesh, Price, Christopher T. D., Jones, Snake C., Wong, Kathy, Gehring, Kalle, Kwaik, Yousef Abu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506055/ https://www.ncbi.nlm.nih.gov/pubmed/28698607 http://dx.doi.org/10.1038/s41598-017-05211-5

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