L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways

Charcot–Marie–Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such as K141N, in the small heat shock protein HSPB8 are known to cause distal hereditary motor neuropathy 2A (dHMN2A) or Charcot-Mari...

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Detalles Bibliográficos
Autores principales: Yang, Xiao-Dong, Cen, Zhi-Dong, Cheng, Hai-Peng, Shi, Kai, Bai, Jie, Xie, Fei, Wu, Hong-Wei, Li, Bei-Bei, Luo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506380/
https://www.ncbi.nlm.nih.gov/pubmed/28747872
http://dx.doi.org/10.3389/fnins.2017.00402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506380/
https://www.ncbi.nlm.nih.gov/pubmed/28747872
http://dx.doi.org/10.3389/fnins.2017.00402

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