Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan

Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non‐neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO (+/−))...

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Detalles Bibliográficos
Autores principales: Merry, Troy L., Kuhlow, Doreen, Laube, Beate, Pöhlmann, Doris, Pfeiffer, Andreas F. H., Kahn, C. Ronald, Ristow, Michael, Zarse, Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506415/
https://www.ncbi.nlm.nih.gov/pubmed/28544360
http://dx.doi.org/10.1111/acel.12610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506415/
https://www.ncbi.nlm.nih.gov/pubmed/28544360
http://dx.doi.org/10.1111/acel.12610

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