Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells

BACKGROUND: Pertussis toxin (PT) is an exotoxin virulence factor produced by Bordetella pertussis, the causative agent of whooping cough. PT consists of an active subunit (S1) that ADP-ribosylates the alpha subunit of several mammalian G proteins, and a B oligomer (S2–S5) that binds glycoconjugate r...

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Detalles Bibliográficos
Autores principales: Carbonetti, Nicholas H, Mays, R Michael, Artamonova, Galina V, Plaut, Roger D, Worthington, Zoë EV
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC550662/
https://www.ncbi.nlm.nih.gov/pubmed/15691377
http://dx.doi.org/10.1186/1471-2180-5-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC550662/
https://www.ncbi.nlm.nih.gov/pubmed/15691377
http://dx.doi.org/10.1186/1471-2180-5-7

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