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Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells
BACKGROUND: Pertussis toxin (PT) is an exotoxin virulence factor produced by Bordetella pertussis, the causative agent of whooping cough. PT consists of an active subunit (S1) that ADP-ribosylates the alpha subunit of several mammalian G proteins, and a B oligomer (S2–S5) that binds glycoconjugate r...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC550662/ https://www.ncbi.nlm.nih.gov/pubmed/15691377 http://dx.doi.org/10.1186/1471-2180-5-7 |