Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

Glycolytic cancer cells produce large quantities of lactate that must be removed to sustain metabolism in the absence of oxidative phosphorylation. The only venting mechanism described to do this at an adequate rate is H(+)-coupled lactate efflux on monocarboxylate transporters (MCTs). Outward MCT a...

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Detalles Bibliográficos
Autores principales: Dovmark, T H, Saccomano, M, Hulikova, A, Alves, F, Swietach, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507299/
https://www.ncbi.nlm.nih.gov/pubmed/28368405
http://dx.doi.org/10.1038/onc.2017.71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507299/
https://www.ncbi.nlm.nih.gov/pubmed/28368405
http://dx.doi.org/10.1038/onc.2017.71

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