Cargando…

Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site

Pyruvate phosphate dikinase (PPDK) is an essential enzyme of C(4) photosynthesis in plants, catalyzing the ATP-driven conversion of pyruvate to phosphoenolpyruvate (PEP). It is further used by some bacteria and unicellular protists in the reverse, ATP-forming direction. Many weed species use C(4) ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Minges, Alexander, Groth, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507339/ https://www.ncbi.nlm.nih.gov/pubmed/28700696 http://dx.doi.org/10.1371/journal.pone.0181139

Ejemplares similares

Structural intermediates and directionality of the swiveling motion of Pyruvate Phosphate Dikinase
por: Minges, Alexander, et al.
Publicado: (2017)

On the potential alternate binding change mechanism in a dimeric structure of Pyruvate Phosphate Dikinase
por: Ciupka, Daniel, et al.
Publicado: (2017)

A New SNP in Rice Gene Encoding Pyruvate Phosphate Dikinase (PPDK) Associated with Floury Endosperm
por: Wang, Heng, et al.
Publicado: (2020)

Disruption of pyruvate phosphate dikinase in Brucella ovis PA CO(2)-dependent and independent strains generates attenuation in the mouse model
por: Vizcaíno, Nieves, et al.
Publicado: (2020)

Production of recombinant Entamoeba histolytica pyruvate phosphate dikinase and its application in a lateral flow dipstick test for amoebic liver abscess
por: Saidin, Syazwan, et al.
Publicado: (2014)

Functional Analysis of H(+)-Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum
por: Kuil, Teun, et al.
Publicado: (2022)

A Novel Mutation of OsPPDKB, Encoding Pyruvate Orthophosphate Dikinase, Affects Metabolism and Structure of Starch in the Rice Endosperm
por: Zhang, Long, et al.
Publicado: (2018)

Allelic variation for alpha-Glucan Water Dikinase is associated with starch phosphate content in tetraploid potato
por: Uitdewilligen, J. G. A. M. L., et al.
Publicado: (2022)

The Fast-Growing Brucella suis Biovar 5 Depends on Phosphoenolpyruvate Carboxykinase and Pyruvate Phosphate Dikinase but Not on Fbp and GlpX Fructose-1,6-Bisphosphatases or Isocitrate Lyase for Full Virulence in Laboratory Models
por: Zúñiga-Ripa, Amaia, et al.
Publicado: (2018)

Differential Evolution of α-Glucan Water Dikinase (GWD) in Plants
por: Adegbaju, Muyiwa S., et al.
Publicado: (2020)

The Pyruvate-Phosphate Dikinase (C(4)-SmPPDK) Gene From Suaeda monoica Enhances Photosynthesis, Carbon Assimilation, and Abiotic Stress Tolerance in a C(3) Plant Under Elevated CO(2) Conditions
por: Yadav, Sonam, et al.
Publicado: (2020)

Erratum To: Production of recombinant Entamoeba histolyticapyruvate phosphate dikinase and its application in a lateral flow dipstick test for amoebic liver abscess
por: Saidin, Syazwan, et al.
Publicado: (2014)

Retraction Note: Production of recombinant Entamoeba histolyticapyruvate phosphate dikinase and its application in a lateral flow dipstick test for amoebic liver abscess
por: Saidin, Syazwan, et al.
Publicado: (2022)

Efficient In Vivo Screening Method for the Identification of C(4) Photosynthesis Inhibitors Based on Cell Suspensions of the Single-Cell C(4) Plant Bienertia sinuspersici
por: Minges, Alexander, et al.
Publicado: (2019)

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
por: Lin, Qingxiang, et al.
Publicado: (2020)

Glucan, Water‐Dikinase 1 (GWD1), an ideal biotechnological target for potential improving yield and quality in rice
por: Wang, Zhen, et al.
Publicado: (2021)

Mutations in Glucan, Water Dikinase Affect Starch Degradation and Gametophore Development in the Moss Physcomitrella patens
por: Mdodana, Ntombizanele T., et al.
Publicado: (2019)

The Importance of Polarity in the Evolution of the K(+) Binding Site of Pyruvate Kinase
por: Ramírez-Silva, Leticia, et al.
Publicado: (2014)

Domain-based small molecule binding site annotation
por: Snyder, Kevin A, et al.
Publicado: (2006)

In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules
por: Vittorio, Serena, et al.
Publicado: (2021)

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1
por: Ammosova, Tatiana, et al.
Publicado: (2012)

How does a small molecule bind at a cryptic binding site?
por: Shan, Yibing, et al.
Publicado: (2022)

Pocketome: an encyclopedia of small-molecule binding sites in 4D
por: Kufareva, Irina, et al.
Publicado: (2012)

Knowledge-based annotation of small molecule binding sites in proteins
por: Thangudu, Ratna R, et al.
Publicado: (2010)

Mapping the 3D structures of small molecule binding sites
por: Meyers, Joshua, et al.
Publicado: (2016)

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site
por: Rippin, Ido, et al.
Publicado: (2020)

Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs
por: Huber, Max E., et al.
Publicado: (2022)

Severe MgADP Inhibition of Bacillus subtilis F(1)-ATPase Is Not Due to the Absence of Nucleotide Binding to the Noncatalytic Nucleotide Binding Sites
por: Ishikawa, Toru, et al.
Publicado: (2014)

Alpha-Glucan, Water Dikinase 1 Affects Starch Metabolism and Storage Root Growth in Cassava (Manihot esculenta Crantz)
por: Zhou, Wenzhi, et al.
Publicado: (2017)

Starch Granule Re-Structuring by Starch Branching Enzyme and Glucan Water Dikinase Modulation Affects Caryopsis Physiology and Metabolism
por: Shaik, Shahnoor S., et al.
Publicado: (2016)

DNA microstructure influences selective binding of small molecules designed to target mixed-site DNA sequences
por: Laughlin-Toth, Sarah, et al.
Publicado: (2017)

Portability of a Small-Molecule Binding Site between Disordered Proteins
por: Jaiprashad, Rajesh, et al.
Publicado: (2022)

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule
por: Ferrandez, Yann, et al.
Publicado: (2017)

Phosphate binding sites identification in protein structures
por: Parca, Luca, et al.
Publicado: (2011)

Dual Effects of Adp and Adenylylimidodiphosphate on Cftr Channel Kinetics Show Binding to Two Different Nucleotide Binding Sites
por: Weinreich, Frank, et al.
Publicado: (1999)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
por: Lin, Xionghao, et al.
Publicado: (2019)

The nucleotide-binding site of Aquifex aeolicus LpxC
por: Buetow, Lori, et al.
Publicado: (2006)

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2
por: Shankar Babu, Mani, et al.
Publicado: (2018)

The Overlap of Small Molecule and Protein Binding Sites within Families of Protein Structures
por: Davis, Fred P., et al.
Publicado: (2010)

Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces
por: Bowkett, David, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q2kfl4c0rfnmo97nbn4s5fqqbi