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NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis

Genome-wide somatic mutation profiles of tumours can now be assessed efficiently and promise to move precision medicine forward. Statistical analysis of mutation profiles is however challenging due to the low frequency of most mutations, the varying mutation rates across tumours, and the presence of...

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Detalles Bibliográficos
Autores principales: Le Morvan, Marine, Zinovyev, Andrei, Vert, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507468/
https://www.ncbi.nlm.nih.gov/pubmed/28650955
http://dx.doi.org/10.1371/journal.pcbi.1005573