Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles

HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has uncovered an unprecedented number of novel HLA class I alleles. Here we define the nature and extent of the variation in...

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Detalles Bibliográficos
Autores principales: Robinson, James, Guethlein, Lisbeth A., Cereb, Nezih, Yang, Soo Young, Norman, Paul J., Marsh, Steven G. E., Parham, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507469/
https://www.ncbi.nlm.nih.gov/pubmed/28650991
http://dx.doi.org/10.1371/journal.pgen.1006862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507469/
https://www.ncbi.nlm.nih.gov/pubmed/28650991
http://dx.doi.org/10.1371/journal.pgen.1006862

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