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Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles
HLA class I glycoproteins contain the functional sites that bind peptide antigens and engage lymphocyte receptors. Recently, clinical application of sequence-based HLA typing has uncovered an unprecedented number of novel HLA class I alleles. Here we define the nature and extent of the variation in...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507469/ https://www.ncbi.nlm.nih.gov/pubmed/28650991 http://dx.doi.org/10.1371/journal.pgen.1006862 |