TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles

Interferon gamma (IFNγ) is the major proinflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the destruction of the parasitophorous vacuole (PV). We previously identified TRIM21 as an IFNγ-driven E3 ubiquitin ligase mediating the deposition...

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Detalles Bibliográficos
Autores principales: Foltz, Clémence, Napolitano, Anna, Khan, Rabia, Clough, Barbara, Hirst, Elizabeth M., Frickel, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507857/
https://www.ncbi.nlm.nih.gov/pubmed/28701773
http://dx.doi.org/10.1038/s41598-017-05487-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507857/
https://www.ncbi.nlm.nih.gov/pubmed/28701773
http://dx.doi.org/10.1038/s41598-017-05487-7

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