Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation

Although ASXL1 mutations are frequently found in human diseases, including myeloid leukemia, the cell proliferation–associated function of ASXL1 is largely unknown. Here, we explored the molecular mechanism underlying the growth defect found in Asxl1-deficient mouse embryonic fibroblasts (MEFs). We...

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Detalles Bibliográficos
Autores principales: Youn, Hye Sook, Kim, Tae-Yoon, Park, Ui-Hyun, Moon, Seung-Tae, An, So-Jung, Lee, Yong-Kyu, Hwang, Jin-Taek, Kim, Eun-Joo, Um, Soo-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507898/
https://www.ncbi.nlm.nih.gov/pubmed/28701722
http://dx.doi.org/10.1038/s41598-017-05564-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507898/
https://www.ncbi.nlm.nih.gov/pubmed/28701722
http://dx.doi.org/10.1038/s41598-017-05564-x

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