Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6

Although we have shown that avian reovirus (ARV) p17-mediated inhibition of Akt leads to induction of autophagy, the precise mechanisms remain largely unknown. This study has identified a specific mechanism by which ARV coordinately regulates the degradation of ribosomal proteins by p17-mediated act...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Ru, Chi, Pei-I, Chiu, Hung-Chuan, Hsu, Jue-Liang, Nielsen, Brent L., Liao, Tsai-Ling, Liu, Hung-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507987/
https://www.ncbi.nlm.nih.gov/pubmed/28701787
http://dx.doi.org/10.1038/s41598-017-05510-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507987/
https://www.ncbi.nlm.nih.gov/pubmed/28701787
http://dx.doi.org/10.1038/s41598-017-05510-x

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