DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients

The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) ag...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Tartaglia, Maria Carmela, Moreno, Danielle, Sato, Christine, McKeever, Paul, Weichert, Anna, Keith, Julia, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508035/
https://www.ncbi.nlm.nih.gov/pubmed/28439722
http://dx.doi.org/10.1007/s00401-017-1713-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508035/
https://www.ncbi.nlm.nih.gov/pubmed/28439722
http://dx.doi.org/10.1007/s00401-017-1713-y

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