The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization

Metabolites can inhibit the enzymes that generate them. To explore the general nature of metabolic self-inhibition, we surveyed enzymological data accrued from a century of experimentation and generated a genome-scale enzyme-inhibition network. Enzyme inhibition is often driven by essential metaboli...

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Detalles Bibliográficos
Autores principales: Alam, Mohammad Tauqeer, Olin-Sandoval, Viridiana, Stincone, Anna, Keller, Markus A., Zelezniak, Aleksej, Luisi, Ben F., Ralser, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508129/
https://www.ncbi.nlm.nih.gov/pubmed/28691704
http://dx.doi.org/10.1038/ncomms16018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508129/
https://www.ncbi.nlm.nih.gov/pubmed/28691704
http://dx.doi.org/10.1038/ncomms16018

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