R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are a common feature of human malignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targets,...

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Detalles Bibliográficos
Autores principales: Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508203/
https://www.ncbi.nlm.nih.gov/pubmed/28695896
http://dx.doi.org/10.1038/ncomms15945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508203/
https://www.ncbi.nlm.nih.gov/pubmed/28695896
http://dx.doi.org/10.1038/ncomms15945

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