Dual loss of human POLQ and LIG4 abolishes random integration

Homologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase...

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Detalles Bibliográficos
Autores principales: Saito, Shinta, Maeda, Ryo, Adachi, Noritaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508229/
https://www.ncbi.nlm.nih.gov/pubmed/28695890
http://dx.doi.org/10.1038/ncomms16112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508229/
https://www.ncbi.nlm.nih.gov/pubmed/28695890
http://dx.doi.org/10.1038/ncomms16112

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